Table 2.

Univariate logistic regression analysis of SNPs in DPYD in cases with severe capecitabine-related toxicity compared with population cohort frequencies

GenotypeLocationEffectCasesCohortUnivariate analysis
n Frequency, % n Frequency, %OR95% CI P
85T>CaExon 2Cys29Arg
 T/T286261611
 T/C+C/C12/53836/3391.00.5–2.0  0.89
IVS4+66G>C Intron 4Unknown
 G/G4498100100
 G/C+C/C1/020/00
IVS5+18G>AIntron 5Unknown
 G/G408992951
 G/A+A/A4/1115/052.30.6–8.40.20
496A>GaExon 6Met166Val
 A/A347684 1841
 A/G+G/G9/2244/2161.70.7–4.00.23
IVS9-51T>GIntron 9unknown
 T/T378695951
 T/G+G/G5/1145/053.10.9–10.70.07
IVS10-15T>CIntron 10Unknown
 T/T317078781
 T/C+C/C10/23020/2221.40.6–3.10.45
1236G>AaExon 11Glu412Glu
 G/G398795951
 G/A+A/A5/1135/052.90.8–10.10.08
IVS11-181C>AIntron 11Unknown
 C/C429899100
 C/A+A/A1/020/00
IVS11-119A>GIntron 11Unknown
 A/A2/09599100
 A/G+G/G2/050/00
IVS11-106T>AIntron 11Unknown
 T/T368482831
 T/A+A/A7/01616/1170.90.4–2.50.90
1601G>AaExon 13Ser534Asn
 G/G419597971
 G/A+A/A2/053/031.60.3–9.80.63
1627A>GaExon 13Ile543Val
 A/A307062621
 A/G+G/G12/13034/4380.70.3–1.50.38
1679T>GExon 13Ile560Ser
 T/T431009999
 T/G+G/G0/001/01
IVS13+39C>TIntron 13Unknown
 C/C307063631
 C/T+T/T12/13033/4370.70.3–1.60.44
IVS13+40A>GIntron 13Unknown
 A/A61419191
 A/G+G/G25/128646/35811.40.5–3.90.47
1896T>CExon 14Phe632Phe
 T/T409190901
 T/C+C/C4/0910/0100.90.3–3.00.87
IVS14+1G>AaIntron 14Exon 14
 G/Gskipping408999991
 G/A+A/A5/0111/01121.4–1090.004
2194G>AaExon 18Val732Ile
 G/G419193931
 G/A+A/A4/097/071.30.4–4.70.69
IVS18-39G>AIntron 18Unknown
 G/G368277811
 G/A+A/A8/01817/1191.00.4–2.40.92
2303C>AExon 19Thr768Lys
 C/C441009499
 C/A+A/A0/001/01
2567C>TExon 20Thr856Ile
 C/C419898100
 C/T+T/T1/020/00
2846A>TaExon 22Asp949Val
 A/A4293100100
 A/T+T/T3/070/00
3338A>G3′ UTRUnknown
 A/A419597971
 A/G+G/G2/053/031.60.3–9.80.63
3453T>C3′ UTRUnknown
 T/T327467671
 T/C+C/C11/02632/1330.70.3–1.60.38
3752G>A3′ UTRUnknown
 G/G368685851
 G/A+A/A6/01415/0150.90.3–2.60.91
3947G>C3′ UTRUnknown
 G/G102423231
 G/C+C/C15/177650/27771.00.4–2.20.92
3959C>T3′ UTRUnknown
 C/C204754541
 C/T+T/T18/55340/6461.40.7–2.80.42
4079T>C3′ UTRUnknown
 T/T34928494b
 T/C+C/C1/282/36
4241A>G3′ UTRUnknown
 A/A369785961
 A/G+G/G1/033/140.60.06–5.50.64
  • aSelected SNPs that were hereafter analyzed in the entire CAIRO2 population (n = 568).

  • bExcluded from analysis because of deviation from Hardy–Weinberg equilibrium.