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OnlineFirst

March 27, 2018

  • Biology of Human Tumors
    TGFβ1 Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy
    Ye Tao, Erich M. Sturgis, Zhigang Huang, Ying Wang, Peng Wei, Jennifer Rui Wang, Qingyi Wei and Guojun Li
    Clin Cancer Res March 27 2018 DOI:10.1158/1078-0432.CCR-17-1904

  • Cancer Therapy: Clinical
    A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia
    Timothy S. Pardee, Rebecca G. Anderson, Kristin M. Pladna, Scott Isom, Lais P. Ghiraldeli, Lance D. Miller, Jeff W. Chou, Guangxu Jin, Wei Zhang, Leslie R. Ellis, Dmitriy Berenzon, Dianna S. Howard, David D. Hurd, Megan Manuel, Sarah Dralle, Susan Lyerly and Bayard L. Powell
    Clin Cancer Res March 27 2018 DOI:10.1158/1078-0432.CCR-17-2282

March 26, 2018

  • Personalized Medicine and Imaging | AUTHOR MANUSCRIPT
    ER+ breast cancers resistant to prolonged neoadjuvant letrozole exhibit an E2F4 transcriptional program sensitive to CDK4/6 inhibitors
    Angel Guerrero-Zotano, Thomas Stricker, Luigi Formisano, Katherine E Hutchinson, Daniel G. Stover, Kyung-min Lee, Luis J Schwarz, Jennifer M. Giltnane, Monica V Estrada, Valerie M Jansen, Alberto Servetto, Joaquín Gavilá, José Alejandro Pérez-Fidalgo, Ana Lluch, Antonio Llombart-Cussac, Mohamed Amine Bayar, Stefan Michiels, Fabrice Andre, Monica Arnedos, Vicente Guillem, Amparo Ruiz-Simon and Carlos L. Arteaga
    Clin Cancer Res March 26 2018 DOI:10.1158/1078-0432.CCR-17-2904

  • Review | AuthorChoice | AUTHOR MANUSCRIPT
    Data Analysis Strategies in Medical Imaging
    Chintan Parmar, Joseph D. Barry, Ahmed Hosny, John Quackenbush and Hugo JWL Aerts
    Clin Cancer Res March 26 2018 DOI:10.1158/1078-0432.CCR-18-0385

  • CCR Translations | AUTHOR MANUSCRIPT
    The long neglected player: modeling tumor uptake to guide optimal dosing
    Leire Ruiz-Cerdá, Eduardo Asin-Prieto, Zinnia P Parra-Guillen and Iñaki F Troconiz
    Clin Cancer Res March 26 2018 DOI:10.1158/1078-0432.CCR-18-0580

  • CCR Translations | AuthorChoice | AUTHOR MANUSCRIPT
    Biomarker discovery from we to me: Is learning from each patient a new approach?
    Stephanie Lheureux
    Clin Cancer Res March 26 2018 DOI:10.1158/1078-0432.CCR-18-0380

March 23, 2018

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
    Malte Mohme, Simon Schliffke, Cecile L Maire, Alessandra Rünger, Laura Glau, Klaus C Mende, Jakob Matschke, Christina Gehbauer, Nuray Akyüz, Svenja Zapf, Mareike Holz, Miriam Schaper, Tobias Martens, Nils O Schmidt, Sven Peine, Manfred Westphal, Mascha Binder, Eva Tolosa and Katrin Lamszus
    Clin Cancer Res March 23 2018 DOI:10.1158/1078-0432.CCR-17-2617

March 22, 2018

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    False positive plasma genotyping due to clonal hematopoiesis
    Yuebi Hu, Bryan Ulrich, Julianna Supplee, Yanan Kuang, Patrick H. Lizotte, Nora Feeney, Nicolas Guibert, Mark M. Awad, Kwok-Kin Wong, Pasi A. Janne, Cloud Peter Paweletz and Geoffrey R. Oxnard
    Clin Cancer Res March 22 2018 DOI:10.1158/1078-0432.CCR-18-0143

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    Epigenome-wide SRC-1 mediated gene silencing represses cellular differentiation in advanced breast cancer
    Elspeth Ward, Damir Vareslija, Sara Charmsaz, Ailis Fagan, Alacoque L Browne, Nicola S Cosgrove, Sinead Cocchiglia, Siobhan P Purcell, Lance Hudson, Sudipto Das, Darran O'Connor, Phillip J O'Halloran, Andrew H Sims, Arnold D. Hill and Leonie S Young
    Clin Cancer Res March 22 2018 DOI:10.1158/1078-0432.CCR-17-2615

March 21, 2018

  • Personalized Medicine and Imaging | AuthorChoice | AUTHOR MANUSCRIPT
    A new approach to predict progression-free survival in stage IV EGFR-mutant NSCLC patients with EGFR-TKI therapy
    Jiangdian Song, Jingyun Shi, Di Dong, Mengjie Fang, Wenzhao Zhong, Kun Wang, Ning Wu, Yanqi Huang, Zhenyu Liu, Yue Cheng, Yuncui Gan, Yongzhao Zhou, Ping Zhou, Bojiang Chen, Changhong Liang, Zaiyi Liu, Weimin Li and Jie Tian
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-2507

  • Cancer Therapy: Preclinical | AUTHOR MANUSCRIPT
    The pattern of Mesenchymal stem cell expression is an independent marker of outcome in multiple myeloma.
    Carolina Schinke, Pingping Qu, Syed J Mehdi, Antje Hoering, Joshua Epstein, Sarah Johnson, Frits van Rhee, Maurizio Zangari, Sharmilan Thanendrarajan, Bart Barlogie, Faith E Davies, Shmuel Yaccoby and Gareth Morgan
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-2627

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-cell Targets in Human IDH-Mutant Glioma
    Steffen Dettling, Slava Stamova, Rolf Warta, Martina Schnölzer, Carmen Rapp, Anchana Rathinasamy, David Reuss, Kolja Pocha, Saskia Roesch, Christine Jungk, Uwe Warnken, Volker Eckstein, Niels Grabe, Christoph Schramm, Markus A. Weigand, Andreas von Deimling, Andreas Unterberg, Philipp Beckhove and Christel Herold-Mende
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-1839

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    COX-2/PGE2 Axis Regulates HIF-2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment
    Zhao-Ru Dong, Xiao-Feng Dong, Tian-Qi Liu, Xu-Ting Zhi, Jie Zou, Jing-Tao Zhong, Tao Li, Xiang-Lan Mo, Wei Zhou, Wen-Wen Guo, Xia Liu, Yuan-Yuan Chen, Meng-Yang Li, Xiao-Gang Zhong, Ya-Min Han and Zhong-Hao Wang
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-2725

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Ensartinib (X-396) in ALK-positive Non-Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study
    Leora Horn, Jeffrey R. Infante, Karen L. Reckamp, George R Blumenshein, Ticiana A Leal, Saiama N Waqar, Barbara J. Gitlitz, Rachel E Sanborn, Jennifer G Whisenant, Liping Du, Joel W. Neal, Jon P Gockerman, Gary Dukart, Kimberly Harrow, Chris Liang, James J Gibbons, Allison Holzhausen, Christine M. Lovly and Heather A. Wakelee
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-2398

  • Cancer Therapy: Preclinical
    Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors
    Tobias Speck, Johannes P.W. Heidbuechel, Rūta Veinalde, Dirk Jaeger, Christof von Kalle, Claudia R. Ball, Guy Ungerechts and Christine E. Engeland
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-2651

  • Biology of Human Tumors
    Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases
    Fengju Chen, Yiqun Zhang, Don L. Gibbons, Benjamin Deneen, David J. Kwiatkowski, Michael Ittmann and Chad J. Creighton
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-3378

  • Personalized Medicine and Imaging | AuthorChoice
    Prediction of Chemotherapeutic Efficacy in Non–Small Cell Lung Cancer by Serum Metabolomic Profiling
    Yanhua Tian, Zhijie Wang, Xiaohui Liu, Jianchun Duan, Guoshuang Feng, Yuxin Yin, Jin Gu, Zhaoli Chen, Shugeng Gao, Hua Bai, Rui Wan, Jun Jiang, Jia Liu, Cong Zhang, Di Wang, Jiefei Han, Xue Zhang, Liangliang Cai, Jie He and Jie Wang
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-2855

  • Biology of Human Tumors
    Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women
    Megan A. Clarke, Ana Gradissimo, Mark Schiffman, Jessica Lam, Christopher C. Sollecito, Barbara Fetterman, Thomas Lorey, Nancy Poitras, Tina R. Raine-Bennett, Philip E. Castle, Nicolas Wentzensen and Robert D. Burk
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-3251

  • Biology of Human Tumors
    Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma
    Wei Guo, Yun-Fan Sun, Min-Na Shen, Xiao-Lu Ma, Jiong Wu, Chun-Yan Zhang, Yan Zhou, Yang Xu, Bo Hu, Min Zhang, Gang Wang, Wei-Qin Chen, Lin Guo, Ren-Quan Lu, Chao-Hui Zhou, Xin Zhang, Ying-Hong Shi, Shuang-jian Qiu, Bai-shen Pan, Ya Cao, Jian Zhou, Xin-Rong Yang and Jia Fan
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-1753

  • Cancer Therapy: Preclinical | AuthorChoice
    Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy
    A. Kenneth MacLeod, De Lin, Jeffrey T.–J. Huang, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf
    Clin Cancer Res March 21 2018 DOI:10.1158/1078-0432.CCR-17-3555

March 20, 2018

  • Clinical Trial Brief Report | AUTHOR MANUSCRIPT
    Anaplastic lymphoma kinase mutation (ALK F1174C) in small cell carcinoma of the prostate and molecular response to alectinib
    Benedito A Carneiro, Sahithi Pamarthy, Ami N Shah, Vinay Sagar, Kenji Unno, HuiYing Han, Ximing J Yang, Rubens B Costa, Rebecca J. Nagy, Richard B. Lanman, Timothy M Kuzel, Jeffrey S. Ross, Laurie Gay, Julia A. Elvin, Siraj M. Ali, Massimo Cristofanilli, Young Kwang Chae, Francis J. Giles and Sarki A. Abdulkadir
    Clin Cancer Res March 20 2018 DOI:10.1158/1078-0432.CCR-18-0332

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogs
    Inge C Van Gool, Emily Rayner, Elisabeth M Osse, Remi A Nout, Carien L Creutzberg, Ian Tomlinson, David N Church, Vincent T.H.B.M. Smit, Niels de Wind, Tjalling Bosse and Mark Drost
    Clin Cancer Res March 20 2018 DOI:10.1158/1078-0432.CCR-18-0266

  • Personalized Medicine and Imaging | AUTHOR MANUSCRIPT
    Improved risk stratification by circulating tumor cell counts in pancreatic cancer
    Katharina E Effenberger, Cornelia Schroeder, Annkathrin Hanssen, Stefan Wolter, Christine Eulenburg, Michael Tachezy, Florian Gebauer, Jakob R. Izbicki, Klaus Pantel and Maximilian Bockhorn
    Clin Cancer Res March 20 2018 DOI:10.1158/1078-0432.CCR-18-0120

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Safety and Antitumor Activity of Pembrolizumab in Patients with Estrogen Receptor‒Positive/Human Epidermal Growth Factor Receptor 2‒Negative Advanced Breast Cancer
    Hope S. Rugo, Jean-Pierre Delord, Seock-Ah Im, Patrick A. Ott, Sarina A. Piha-Paul, Phillipe L. Bedard, Jasgit Sachev, Christophe Le Tourneau, Emilie M.J. van Brummelen, Andreea Varga, Roberto Salgado, Sherene Loi, Sanatan Saraf, Dina Pietrangelo, Vassiliki Karantza and Antoinette R Tan
    Clin Cancer Res March 20 2018 DOI:10.1158/1078-0432.CCR-17-3452

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined With Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors
    David M. Hyman, Naiyer A. Rizvi, Ronald B. Natale, Deborah K. Armstrong, Michael J Birrer, Lawrence Recht, Efrat Dotan, Vicky Makker, Thomas J Kaley, Denison Kuruvilla, Matthew Gribbin, Jennifer McDevitt, Dominic W. Lai and Mohammed M Dar
    Clin Cancer Res March 20 2018 DOI:10.1158/1078-0432.CCR-17-1775

March 19, 2018

  • Cancer Therapy: Preclinical | AuthorChoice | AUTHOR MANUSCRIPT
    Targeting bromodomain and extra-terminal (BET) family proteins in castration resistant prostate cancer (CRPC)
    Jonathan Welti, Adam Sharp, Wei Yuan, David I Dolling, Daniel Nava Rodrigues, Ines Figueiredo, Veronica Gil, Antje Neeb, Matthew Clarke, George Seed, Mateus Crespo, Semini Sumanasuriya, Jian Ning, Eleanor Knight, Jeffrey C Francis, Ashley Hughes, Wendy S Halsey, Alec Paschalis, Ram S Mani, Ganesh V Raj, Steve Plymate, Suzanne Carreira, Gunther Boysen, Arul M. Chinnaiyan, Amanda Swain and Johann S. de Bono
    Clin Cancer Res March 19 2018 DOI:10.1158/1078-0432.CCR-17-3571

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression
    Stephen Keysar, Justin Eagles, Bettina Miller, Brian C Jackson, Farshad N Chowdhury, Julie Reisinger, Tugs-Saikhan Chimed, Phuong N. Le, J. Jason Morton, Hilary Somerset, Marileila Varella-Garcia, Aik-Choon Tan, John I. Song, Daniel W. Bowles, Mary E. Reyland and Antonio Jimeno
    Clin Cancer Res March 19 2018 DOI:10.1158/1078-0432.CCR-17-3871

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Impact of donor type in patients with AML given allogeneic hematopoietic cell transplantation after low-dose TBI based regimen
    Frederic Baron, Myriam Labopin, Annalisa Ruggeri, Jan J. Cornelissen, Ellen Meijer, Henrik Sengeloev, Dietger Niederwieser, Marco R de Groot, Harry C. Schouten, Noel-Jean Milpied, Didier Blaise, Bipin Savani, Eliane Gluckman, Mohamad Mohty and Arnon Nagler
    Clin Cancer Res March 19 2018 DOI:10.1158/1078-0432.CCR-17-3622

March 16, 2018

  • Cancer Therapy: Preclinical | AUTHOR MANUSCRIPT
    Dual inhibition of IGF-1R and ErbB3 enhances the activity of gemcitabine and nab-paclitaxel in preclinical models of pancreatic cancer
    Adam J Camblin, Emily A Pace, Sharlene Adams, Michael D. Curley, Victoria Rimkunas, Lin Nie, Gege Tan, Troy Bloom, Sergio Iadevaia, Jason Baum, Charlene Minx, Akos Czibere, Chrystal U Louis, Daryl C Drummond, Ulrik B Nielsen, Birgit Schoeberl, J. Marc Pipas, Robert M. Straubinger, Vasileios Askoxylakis and Alexey A Lugovskoy
    Clin Cancer Res March 16 2018 DOI:10.1158/1078-0432.CCR-17-2262

  • Cancer Therapy: Preclinical | AuthorChoice | AUTHOR MANUSCRIPT
    RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer
    Vincenzo Carafa, Angela Nebbioso, Francesca Cuomo, Dante Rotili, Gilda Cobellis, Paola Bontempo, Alfonso Baldi, Enrico P. Spugnini, Gennaro Citro, Angela Chambery, Rosita Russo, Menotti Ruvo, Paolo Ciana, Luca Maravigna, Jani Shaik, Enrico Radaelli, Pasqualino De Antonellis, Domenico Tarantino, Adele Pirolli, Rino Ragno, Massimo Zollo, Hendrik G. Stunnenberg, Antonello Mai and Lucia Altucci
    Clin Cancer Res March 16 2018 DOI:10.1158/1078-0432.CCR-17-3081

  • CCR Translations | AUTHOR MANUSCRIPT
    REVISITING INTERLEUKIN-12 AS A CANCER IMMUNOTHERAPY AGENT
    Pedro Berraondo, Inaki Etxeberria, Mariano Ponz-Sarvise and Ignacio Melero
    Clin Cancer Res March 16 2018 DOI:10.1158/1078-0432.CCR-18-0381

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    A Novel TGF-β Trap Blocks Chemotherapeutics-Induced TGF-β1 Signaling and Enhances Their Anticancer Activity in Gynecological Cancers
    Haiyan Zhu, Xiang Gu, Lu Xia, You Zhou, Hakim Bouamar, Junhua Yang, Xiaofei Ding, Christian Zwieb, Jianan Zhang, Andrew P. Hinck, LuZhe Sun and Xueqiong Zhu
    Clin Cancer Res March 16 2018 DOI:10.1158/1078-0432.CCR-17-3112

March 15, 2018

  • Personalized Medicine and Imaging | AUTHOR MANUSCRIPT
    Multivalent binding and biomimetic cell rolling improves the sensitivity and specificity of circulating tumor cell capture
    Ja Hye Myung, Michael J. Eblan, Joseph M Caster, sinjung park, Michael J Poellmann, Kyle Wang, Joel E Tepper, Kevin A Tam, Seth M Miller, Colette Shen, Ronald C Chen, Tian Zhang, Bhishamjit Chera, Andrew Z Wang and Seungpyo Hong
    Clin Cancer Res March 15 2018 DOI:10.1158/1078-0432.CCR-17-3078

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    Folate Receptor Alpha Peptide Vaccine generates immunity in Breast and Ovarian Cancer Patients
    Kimberly R. Kalli, Matthew S. Block, Pashtoon M. Kasi, Courtney L. Erskine, Timothy J Hobday, Allan Dietz, Douglas Padley, Michael P. Gustafson, Barath Shreeder, Danell Puglisi-Knutson, Daniel W. Visscher, Toni Kay Mangskau, Glynn Wilson and Keith L Knutson
    Clin Cancer Res March 15 2018 DOI:10.1158/1078-0432.CCR-17-2499

March 13, 2018

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    Exosome-based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients
    Elena Castellanos-Rizaldos, Dominik G. Grimm, Vasisht Tadigotla, James Hurley, John Healy, Patricia L Neal, Mia Sher, Raajdeep Venkatesan, Chris Karlovich, Mitch Raponi, Anne K. Krug, Mikkel Noerholm, Jihane Tannous, Bakhos A. Tannous, Luis E. Raez and Johan Skog
    Clin Cancer Res March 13 2018 DOI:10.1158/1078-0432.CCR-17-3369

  • Personalized Medicine and Imaging | AuthorChoice | AUTHOR MANUSCRIPT
    p95HER2 methionine 611 carboxy-terminal fragment is predictive of trastuzumab adjuvant treatment benefit in the FinHer trial
    Jeff Sperinde, Weidong Huang, Aki Vehtari, Ahmed Chenna, Pirkko-Liisa Kellokumpu-Lehtinen, John Winslow, Petri Bono, Yolanda Lie, Christos J Petropoulos, Jodi Marie Weidler and Heikki Joensuu
    Clin Cancer Res March 13 2018 DOI:10.1158/1078-0432.CCR-17-3250

  • Cancer Therapy: Preclinical | AUTHOR MANUSCRIPT
    Endogenous replication stress marks melanomas sensitive to CHK1 inhibitors in vivo
    Zay Yar Oo, Alexander J Stevenson, Martina A Proctor, Sheena M Daignault, Sebastian Walpole, Catherine Lanagan, Mu-Su Chen, Dubravka Skalamera, Loredana Spoerri, Stephen Ainger, Richard A Sturm, Nikolas K Haass and Brian Gabrielli
    Clin Cancer Res March 13 2018 DOI:10.1158/1078-0432.CCR-17-2701

  • Perspective | AUTHOR MANUSCRIPT
    Report of the 14th International Conference on Malignant Lymphoma (ICML) closed workshop on future design of clinical trials in lymphomas.
    Anastasios Stathis, Alexia Iasonos, John F. Seymour, Catherine Thieblemont, Vincent Ribrag, Emanuele Zucca and Anas Younes
    Clin Cancer Res March 13 2018 DOI:10.1158/1078-0432.CCR-17-3021

  • Cancer Therapy: Clinical | AuthorChoice | AUTHOR MANUSCRIPT
    A Phase I Clinical Trial of AZD1775 in Combination With Neoadjuvant Weekly Docetaxel and Cisplatin Before Definitive Therapy in Head and Neck Squamous Cell Carcinoma
    Eduardo Méndez, Cristina P Rodriguez, Micheal Kao, Sharat C Raju, Ahmed Diab, Richard A Harbison, Eric Q Konnick, Ganesh Mugundu, Rafael Santana-Davila, Renato Martins, Neal D Futran and Laura Q.M. Chow
    Clin Cancer Res March 13 2018 DOI:10.1158/1078-0432.CCR-17-3796

March 12, 2018

  • Biology of Human Tumors | AUTHOR MANUSCRIPT
    Lipidomic profiling links the Fanconi anemia pathway to glycosphingolipid metabolism in head and neck cancer cells
    Xueheng Zhao, Marion G Brusadelli, Sharon L. Sauter, Melinda Butsch Kovacic, Wujuan Zhang, Lindsey E Romick-Rosendale, Paul F Lambert, Kenneth D. Setchell and Susanne I Wells
    Clin Cancer Res March 12 2018 DOI:10.1158/1078-0432.CCR-17-3686

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    High p95HER2/HER2 Ratio Associated With Poor Outcome in Trastuzumab-Treated HER2-Positive Metastatic Breast Cancer NCCTG N0337 and NCCTG 98-32-52 (Alliance)
    Saranya Chumsri, Jeff Sperinde, Heshan Liu, Joseph Gligorov, Jean-Philippe Spano, Martine Antoine, Alvaro Moreno-Aspita, Winston Tan, John Winslow, Christos J Petropoulos, Ahmed Chenna, Michael Bates, Jodi Marie Weidler, Weidong Huang, Amylou C. Dueck and Edith A Perez
    Clin Cancer Res March 12 2018 DOI:10.1158/1078-0432.CCR-17-1864

  • Personalized Medicine and Imaging | AUTHOR MANUSCRIPT
    Association of p27 and cyclin D1 expression and benefit from adjuvant trastuzumab treatment in HER2-positive early breast cancer: a TransHERA study
    Martin Filipits, Urania Dafni, Michael Gnant, Varvara Polydoropoulou, Margaret Hills, Astrid Kiermaier, Evandro De Azambuja, Denis P Larsimont, Federico Rojo, Giuseppe Viale, Masakazu Toi, Nadia Harbeck, Kathleen I Pritchard, Richard D Gelber, Phuong Dinh, Dimitrios Zardavas, Brian Leyland-Jones, Martine Piccart-Gebhart and Mitch Dowsett
    Clin Cancer Res March 12 2018 DOI:10.1158/1078-0432.CCR-17-3473

  • Personalized Medicine and Imaging | AUTHOR MANUSCRIPT
    Concurrent alterations in EGFR-mutant lung cancers associated with resistance to EGFR kinase inhibitors and characterization of MTOR as a mediator of resistance.
    Helena Yu, Ken Suzawa, Emmet J Jordan, Ahmet Zehir, Andy Ni, Hyunjae Ryan Kim, Mark G. Kris, Matthew D. Hellmann, Bob T. Li, Romel Somwar, David B. Solit, Michael F. Berger, Maria E. Arcila, Gregory J. Riely and Marc Ladanyi
    Clin Cancer Res March 12 2018 DOI:10.1158/1078-0432.CCR-17-2961

March 09, 2018

  • CCR Translations | AUTHOR MANUSCRIPT
    Goldilocks Dosing of TKIs: A Dose that is Just Right Leads to Optimal Outcomes
    Brian I. Rini
    Clin Cancer Res March 9 2018 DOI:10.1158/1078-0432.CCR-18-0291

  • CCR Drug Updates | AUTHOR MANUSCRIPT
    U.S. Food and Drug Administration Approval: Neratinib for the Extended Adjuvant Treatment of Early Stage HER2-Positive Breast Cancer
    Harpreet Singh, Amanda J. Walker, Laleh Amiri-Kordestani, Joyce Cheng, Shenghui Tang, Pamela Balcazar, Kimberly Barnett-Ringgold, Todd R. Palmby, Xianhua Cao, Nan Zheng, Qi Liu, Jingyu Yu, William F Pierce, Selena R. Daniels, Rajeshwari Sridhara, Amna Ibrahim, Paul G. Kluetz, Gideon M. Blumenthal, Julia A Beaver and Richard Pazdur
    Clin Cancer Res March 9 2018 DOI:10.1158/1078-0432.CCR-17-3628

March 07, 2018

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Genome-wide discovery and identification of a novel miRNA signature for recurrence prediction in stage II and III colorectal cancer
    Raju Kandimalla, Feng Gao, Takatoshi Matsuyama, Toshiaki Ishikawa, Hiroyuki Uetake, Naoki Takahashi, Yasuhide Yamada, Carlos R Becerra, Scott Kopetz, Xin Wang and Ajay Goel
    Clin Cancer Res March 7 2018 DOI:10.1158/1078-0432.CCR-17-3236

  • Cancer Therapy: Clinical | AUTHOR MANUSCRIPT
    Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle Invasive Bladder Cancer
    Hangcheng Fu, Yu Zhu, Yiwei Wang, Zheng Liu, Junyu Zhang, Huyang Xie, Qiang Fu, Bo Dai, Dingwei Ye and Jiejie Xu
    Clin Cancer Res March 7 2018 DOI:10.1158/1078-0432.CCR-17-2687

March 05, 2018

  • Personalized Medicine and Imaging | AuthorChoice | AUTHOR MANUSCRIPT
    Investigating novel resistance mechanisms to third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer patients
    Zhe Yang, Nong Yang, Qiuxiang Ou, Yi Xiang, Tao Jiang, Xue Wu, Hua Bao, Xiaoling Tong, Xiaonan Wang, Yang W Shao, Yunpeng Liu, Yan Wang and Caicun Zhou
    Clin Cancer Res March 5 2018 DOI:10.1158/1078-0432.CCR-17-2310

March 02, 2018

  • CCR Translations | AUTHOR MANUSCRIPT
    Sequencing pancreatic juice: squeezing the most out of surveillance
    Matthew B Lipner and Jen Jen Yeh
    Clin Cancer Res March 2 2018 DOI:10.1158/1078-0432.CCR-18-0215

March 01, 2018

  • Biology of Human Tumors | AuthorChoice | AUTHOR MANUSCRIPT
    The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression
    Lu Huang, Shruti Malu, Jodi A. McKenzie, Miles C Andrews, Amjad H. Talukder, Trang Tieu, Tatiana V. Karpinets, Cara Haymaker, Marie-Andrée Forget, Leila J. Williams, Zhe Wang, Rina Mbofung, Zhi-Qiang Wang, R. Eric Davis, Roger S. Lo, Jennifer A. Wargo, Michael A. Davies, Chantale Bernatchez, Timothy P. Heffernan, Rodabe N. Amaria, Anil Korkut, Weiyi Peng, Jason Roszik, Gregory Lizee, Scott E. Woodman and Patrick Hwu
    Clin Cancer Res March 1 2018 DOI:10.1158/1078-0432.CCR-17-2483

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OnlineFirst articles are published online before they appear in a regular issue of the journal. Clinical Cancer Research publishes two types of OnlineFirst articles.

OnlineFirst Author Manuscripts are PDF versions of manuscripts that have been peer reviewed and accepted for publication, but not yet copyedited or typeset, allowing readers the most rapid access to accepted papers. They appear on the OnlineFirst page as submitted by the authors. The Author Manuscript remains on the OnlineFirst page until it is either replaced by the final proof version or when the final version of the paper is published in an online issue.

Please note that while we strive to post all accepted manuscripts within two days of their acceptance, there may be editorial considerations, such as a planned press release or the need to coordinate posting of related articles, which may preclude or delay Author Manuscript posting.

Author Manuscripts are normally replaced on the OnlineFirst page by the final proof version of the article, which incorporates author corrections but is not yet paginated.

When papers are published in an issue, they are removed from the OnlineFirst page and appear in the appropriate issue's table of contents. The date of first publication appears below each title, followed by the article's unique Digital Object Identifier (DOI).

While an article is OnlineFirst, it may be cited as shown in the following example:

Park E-K, Thomas PS, Johnson AR, Yates DH. Osteopontin Levels in an Asbestos Exposed Population. (January 27, 2009) Clin Cancer Res, 10.1158/1078-0432.CCR-08-0360.

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Copyright © 2018 by the American Association for Cancer Research.

Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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